CA IONS STABILIZE THE BINDING OF COMPLEMENT FACTOR IC3B TO THE PSEUDOHYPHAL FORM OF CANDIDA-ALBICANS

Authors
SPOTL L MOST J DIERICH MP
Citation
L. Spotl et al., CA IONS STABILIZE THE BINDING OF COMPLEMENT FACTOR IC3B TO THE PSEUDOHYPHAL FORM OF CANDIDA-ALBICANS, Infection and immunity, 62(3), 1994, pp. 1125-1127
Citations number
27
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
62
Issue
3
Year of publication
1994
Pages
1125 - 1127
Database
ISI
SICI code
0019-9567(1994)62:3<1125:CISTBO>2.0.ZU;2-R
Abstract
The pseudohyphal form of Candida albicans is able to bind iC3b. This m ay play an important role in the pathogenesis of disseminated candidia sis and, in particular, in adherence to endothelium, protection agains t complement action, and iron acquisition from erythrocytes. Here we r eport that Ca2+ ions are required to maintain stable binding of iC3b t o C. albicans pseudohyphae.