ROLE OF VASOACTIVE-INTESTINAL-PEPTIDE IN THE GROWTH OF HUMAN PANCREATIC AND COLON-CARCINOMA CELLS, DOES AN AUTOCRINE MECHANISM EXIST

Authors
CHEN YF ZHOU ZC CHEN Q ZHENG J LU GJ FAN ZF
Citation
Yf. Chen et al., ROLE OF VASOACTIVE-INTESTINAL-PEPTIDE IN THE GROWTH OF HUMAN PANCREATIC AND COLON-CARCINOMA CELLS, DOES AN AUTOCRINE MECHANISM EXIST, Biomedical research, 14, 1993, pp. 117-121
Citations number
19
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Biomedical research → ACNP
ISSN journal
03886107
Volume
14
Year of publication
1993
Supplement
3
Pages
117 - 121
Database
ISI
SICI code
0388-6107(1993)14:<117:ROVITG>2.0.ZU;2-6
Abstract
VIP stimulates the growth of human pancreatic and colon carcinoma eels which express VIP receptors, but does not stimulate growth in cell li nes which do not express VIP receptors. This growth-promoting effect m ay be diminished by a specific VIP receptor antagonist, 4-Cl-D-Phe(6), Leu(17)-VIP. While tumor cells were cultured in serum-free media, VIP was secreted into the media. VIP antiserum added to culture medium inh ibits cell growth significantly, suggestive of an autocrine-regulatory role of VIP in tumor cell growth. The post-receptor intracellular mec hanisms of VIP-induced tumor cell growth might involve an increase in cAMP and polyamine production in these cells.