PLASMA GUT HORMONE LEVELS BEFORE AND AFTER DUODENOJEJUNOSTOMY IN PATIENTS WITH JUXTAPAPILLARY DUODENAL DIVERTICULUM

For clarification of the etiology of juxtapapillary duodenal diverticu la (JPD), intraduodenal pressure and fasting phasic motility, particul arly in phase III (migrating motor complex, MMC) were recorded using a micro-tip transducer in 15 normal subjects and 5 patients with JPD. P lasma motilin and somatostatin levels were measured when phase I or In was shown. A duodenojejunostomy was performed without invading the di verticulum. The usefulness of this surgical method was assessed based on changes before and after surgery during MMC and the plasma levels o f motilin and somatostatin. The following results were obtained. 1) Pa tients with JPD showed that MMC occurred more frequently and maximum c ontraction pressure increased 2) With levels higher for JPD, motilin a nd somatostatin contributed to the onset of MMC. 3) Duodenojejunostomy was confirmed to be clinically and physiologically effective for trea ting JPD, as evident from the findings that showed surgery improved MM C and reduced the levels of motilin and somatostatin to essentially th ose of the control.