INHIBITION OF CUTICULAR LIPID-SYNTHESIS AND ITS EFFECT ON INSECT SURVIVAL

A new approach to insect control-using sodium trichloroacetate (NaTCA) to inhibit synthesis of the hydrophobic cuticular lipids that protect insects from dehydration-was tested on Triatoma infestans. In vivo an d in vitro studies of incorporation of radioactive precursors showed d iminished cuticular hydrocarbon synthesis after NaTCA treatment. Thin layer chromatography and scanning electron microscopy showed disruptio n of the cuticular lipid layer of NaTCA-treated insects, which also ha ve increased mortality and altered molting cycles. NaTCA treatment enh anced the penetration and increased the lethality of a contact insecti cide. (C) 1994 Wiley-Liss, Inc.