PLATELET-FUNCTION IN PATIENTS WITH HYPERCHOLESTEROLEMIA

Platelets and plasma lipoproteins, particularly low density lipoprotei n, have important roles in atherogenesis. Evidence from several source s suggests that important interactions occur between these individual components of the atherogeneic process. Here we review work from our o wn laboratory on platelet function in normal individuals and patients heterozygous for familial hypercholesterolaemi a (FH). Data is present ed on the role of platelet noradrenaline and also on altered cellular signalling in platelets from FH individuals who have plasma low densit y lipoprotein concentrations which are approximately double those seen in normal subjects.