TESTOSTERONE TREATMENT ENHANCES THROMBOXANE A(2) MIMETIC INDUCED CORONARY-ARTERY VASOCONSTRICTION IN GUINEA-PIGS

Authors
SCHROR K MORINELLI TA MASUDA A MATSUDA K MATHUR RS HALUSHKA PV
Citation
K. Schror et al., TESTOSTERONE TREATMENT ENHANCES THROMBOXANE A(2) MIMETIC INDUCED CORONARY-ARTERY VASOCONSTRICTION IN GUINEA-PIGS, European journal of clinical investigation, 24, 1994, pp. 50-52
Citations number
18
Categorie Soggetti
Medicine, Research & Experimental
Journal title
European journal of clinical investigation → ACNP
ISSN journal
00142972
Volume
24
Year of publication
1994
Supplement
1
Pages
50 - 52
Database
ISI
SICI code
0014-2972(1994)24:<50:TTETAM>2.0.ZU;2-F
Abstract
Thromboxane A(2) (TXA(2)) has been implicated as an important mediator of cardiovascular diseases. There have been several clinical reports of acute myocardial infarctions occurring in young male athletes abusi ng anabolic steroids. The effects of treatment of male Guinea pigs wit h testosterone on the responses to U46619, a TXA(2) receptor agonist, in the isolated perfused heart were determined. The maximum presser re sponses of the isolated perfused Guinea pig heart to U46619 were signi ficantly (P<0.05) greater in the Guinea pigs treated with testosterone compared to the controls. These results indicate that testosterone ca n enhance coronary artery vascular reactivity to TXA(2).