Am. Bollen et Dr. Eyre, BONE-RESORPTION RATES IN CHILDREN MONITORED BY THE URINARY ASSAY OF COLLAGEN TYPE-1 CROSS-LINKED PEPTIDES, Bone, 15(1), 1994, pp. 31-34
When bone is resorbed, cross-linking amino acids from collagen type I(
pyridinolines) are excreted in the urine as small peptides. The purpos
e of this cross-sectional study was to measure the urinary excretion o
f type I collagen bone degradation products in children and to correla
te the results with growth velocity on a population basis. Spot urines
from 1076 children and 24 adults were analyzed. The concentrations of
cross-linked N-telopeptides of collage type I were measured using a n
ew monoclonal antibody-based microtiter-plate assay, and normalized to
creatinine. Age-related changes in cross-link excretion mirrored publ
ished standard growth velocity rates for males and females. The correl
ation coefficient between growth rates and cross-link excretion was 0.
91. These results encourage more definitive longitudinal studies where
growth rates and collagen cross-link excretion are correlated on an i
ndividual-patient basis.