LONG-LASTING EFFECTS OF AUDIOGENIC-SEIZURES ON BIOGENIC-AMINES IN RB MICE

The existence of long-lasting (15-18 h) alterations of biogenic amines levels following a single or repeated acoustic stimulations in audiog enic seizure-prone Rbl and Rb2 mice and seizure-resistant Rb3 mice wer e investigated. The levels of 5-HT, DA, NE, and of some of their catab olites: 5-HIAA, DOPAC, were determined, as well as changes in synthesi s and utilization indices of 5-HT and DA, in 14 brain areas. Increased NE Levels were observed after a single seizure in Rb2 mice, in the fr ontal cortex, hypothalamus, raphe and after repeated seizures in Rbl i n frontal cortex, raphe, striatum and in Rb2 in hypothalamus, inferior colliculus. Only rare alterations of 5-HT neurotransmission were reco rded after a single or repeated seizures, in the raphe and superior co lliculus. DA neurotransmission is more affected after repeated seizure s, namely in frontal cortex, striatum, hypothalamus, inferior collicul us, raphe, olfactory tubercles, amygdala, and thalamus than after a si ngle one (frontal cortex, amygdala, thalamus, raphe). In Rb3 mice, res istant to sonic stimulations, biogenic amines alterations were rare. T aken all together, a single seizure induced scarce long-lasting altera tions in biogenic amines levels. They were more frequent after repeate d seizure.