STEROID WITHDRAWAL IN THE PEDIATRIC HEART-TRANSPLANT RECIPIENT INITIALLY TREATED WITH TRIPLE IMMUNOSUPPRESSION

We prospectively evaluated the feasibility of withdrawing steroids 6 t o 12 months after heart transplantation in 26 consecutive infants and children (median age at transplantation 6 weeks; range 5 days to 10.1 years) initially treated with triple immunosuppression (cyclosporine, azathioprine, and corticosteroids). Ongoing surveillance for cellular rejection was performed by endomyocardial biopsy in all patients and w as performed electively in all subjects within 2 weeks after administr ation of steroids was discontinued. Significant rejection was defined as grade 2. Twenty-three of 26 patients were 6-month survivors and ste roids were withdrawn in 21, with the other two survivors followed up e lsewhere with triple immunosuppression. Seventeen (81%) of 21 patients were ultimately treated without maintenance steroids for a mean durat ion of 17 months (range 1 to 34 months), including 6 of 17 patients wh o had at least one episode of rejection within the first 6 months of t ransplantation. Five (24%) of 21 patients had rejection 2 weeks (n = 3 ) and 6 months (n = 2) after steroids were withdrawn, with one patient successfully withdrawn from steroids after a second attempt. In this latter group one patient underwent retransplantation because of severe coronary arteriopathy by angiography 10 months after transplantation and another died suddenly 18 months after transplantation despite resu mption of steroids. Age, timing of steroid withdrawal after transplant ation, number of rejection episodes before steroid withdrawal, the pri or presence of plasma-reactive antibodies, the number of histocompatib ility leukocyte antigen matches, and the leukocyte antigen number with positive B or T cell cross-matches between the two groups were not si gnificantly different between the children with rejection and those wi th no rejection after steroid withdrawal. From these findings we concl ude that steroids can be withdrawn successfully in most, but not all, infants and young children undergoing heart transplantation initially treated with triple immunosuppression therapy. However, a prospective way to determine the likelihood of successful steroid withdrawal for a n individual patient could not be determined.