PARENTERAL THERAPY OF MODERATELY SEVERE MALARIA - COMPARISON OF INTRAMUSCULAR ARTEMETHER AND INTRAMUSCULAR SULFADOXINE-PYRIMETHAMINE

Authors
SALAKO LA WALKER O SOWUNMI A
Citation
La. Salako et al., PARENTERAL THERAPY OF MODERATELY SEVERE MALARIA - COMPARISON OF INTRAMUSCULAR ARTEMETHER AND INTRAMUSCULAR SULFADOXINE-PYRIMETHAMINE, Transactions of the Royal Society of Tropical Medicine and Hygiene, 88(1), 1994, pp. 89-91
Citations number
12
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
Journal title
Transactions of the Royal Society of Tropical Medicine and Hygiene → ACNP
ISSN journal
00359203
Volume
88
Issue
1
Year of publication
1994
Pages
89 - 91
Database
ISI
SICI code
0035-9203(1994)88:1<89:PTOMSM>2.0.ZU;2-P
Abstract
We have compared the efficacy of intramuscular artemether against intr amuscular sulfadoxine-pyrimethamine in an open randomized study in chi ldren with severe but uncomplicated malaria. Parasite clearance time a nd fever clearance time were faster with artemether. The parasitologic al clearance on day 14 was 100% for artemether and 98% for sulfadoxine -pyrimethamine, but 8 patients in the artemether group and 1 in the ot her group had a recrudescence of parasitaemia. There was no toxic reac tion of note in either group. We therefore suggest that artemether is a good alternative to the currently used drugs in the parenteral treat ment of severe but uncomplicated malaria and may be useful in preventi ng the possible development of cerebral malaria.