EFFECTS OF FEMALE SEX-HORMONES IN WHOLE-EMBRYO CULTURE

Citation
Hc. Bowden et al., EFFECTS OF FEMALE SEX-HORMONES IN WHOLE-EMBRYO CULTURE, Toxicology in vitro, 7(6), 1993, pp. 799-802
Citations number
23
Categorie Soggetti
Toxicology
Journal title
ISSN journal
08872333
Volume
7
Issue
6
Year of publication
1993
Pages
799 - 802
Database
ISI
SICI code
0887-2333(1993)7:6<799:EOFSIW>2.0.ZU;2-F
Abstract
Much work has been done in vivo on the effects of sex steroids on the developing foetus. Many genital anomalies have been reported; defects of other organ systems have been suggested. Synthetic oestrogens are c onsidered to be developmental toxicants in vivo, while natural oestrog ens are thought to present little or no risk. A small selection of hor mones (17 beta-oestradiol, 17 alpha-ethynyloestradiol, diethylstilboes trol and progesterone) was tested using the rat whole embryo culture t echnique to see whether this difference could also be confirmed in vit ro. Dysmorphogenic embryotoxic effects were evident with both natural and synthetic oestrogens, but at much higher concentrations than would be expected to circulate in humans after therapeutic use.