ADENOMATOUS HYPERPLASIA OF THE LIVER IN A PATIENT WITH CONGENITAL HEPATIC-FIBROSIS

We report the case of a 30-year-old man suffering from congenital hepa tic fibrosis, who was treated at age 12 by splenorenal shunt for porta l hypertension, and who developed numerous, large hepatic nodules. The patient underwent liver transplantation because of recurrent episodes of acute cholangitis and the presence of foci of dysplasia in the nod ules. Histological examination of the surgical specimen showed adenoma tous hyperplastic nodules with a few atypical foci in an otherwise fib rous but non-cirrhotic liver. Such lesions have not yet been described in congenital hepatic fibrosis. The respective roles of congenital he patic fibrosis and splenorenal shunts in the development of these nodu les are discussed. (C) Journal of Hepatology.