SURVIVAL AFTER PBSC TRANSPLANTATION AND COMPARISON OF ENGRAFTMENT SPEED WITH AUTOLOGOUS AND ALLOGENEIC MARROW TRANSPLANTATION - RESULTS OF A MULTICENTER STUDY

We have analyzed the results of a multicenter study on peripheral bloo d stem cell transplantation (PBSCT) performed on 55 patients suffering from various neoplastic diseases. After myeloablative therapy, they r eceived a mediam of 6.8x10(8)/kg MNC and 11.4x10(4)/kg CFU-GM harveste d by a median of 9 apheresis after mobilization with chemotherapy alon e. As of date, 34 of the 55 patients are alive and 28 of them are in c ontinuous complete remission after a followup of 30 months. The probab ility of survival was related to the disease status at transplant, CR/ PR vs. PD (p=0.0001) and the bone marrow involvement, BM-vs. BM+ (P=0. 009). Furthermore, a comparative study on speed of engraftment and cli nical management was conducted on the 55 PBSCT patients as well as on 41 autoBMT and 52 alloBMT patients. Days to reach WBC>1.0x10(9)/L, PMN >0.5x10(9)/L and PLT>50x10(9)/L was 12/14/33 for PBSGT, 17/20/23 for A BMT and 15/16.5/18 for BMT, respectively. Days with fever >38 degrees C, systemic antibiotic therapy and length of hospitalization was 3/12/ 36 for PBSCT, 5/18.5/42 for ABMT and 9/25/46 for BMT respectively.