ANALYSIS OF HYBRIDS OF CANDIDA-ALBICANS FORMED BY PROTOPLAST FUSION

A number of hybrids obtained by fusion of protoplasts of complementary auxotrophic strains of Candida albicans were analysed for growth rate s, cell volume, DNA content, stability and adherence to human buccal e pithelial cells. SDS-PAGE analysis of the cell wall proteins indicated that the hybrid cell walls contained many more of the proteins associ ated with one parent than the other. The adherence values of the hybri ds were closest to the parent with which they shared most cell wall pr oteins and it is suggested that the hybrids contain the genome of this parent along with one or more of the chromosomes of the other.