The genes encoding the two terminal oxidases of Sulfolobus acidocaldar
ius and their products are characterized. Both archaeal complexes, Sox
ABCD and SoxM, are homologous to the superfamily of haem-copper oxidas
es. They have unusual subunit compositions. Highly conserved sequence
patterns of SoxABCD and SoxM, corresponding to the redox centre bindin
g sites of the catalytical subunit I are compared with other oxidases
of the family. Distance analysis suggests that both Sulfolobus oxidase
s belong to two different subgroups.