INTERFACE BETWEEN THE FACIAL-NERVE AND LARGE ACOUSTIC NEURINOMAS - IMMUNOHISTOCHEMICAL STUDY OF THE CLEAVAGE PLANE IN NF2 AND NON-NF2 CASES

In acoustic neurinoma surgery, the surgeon is required to find a cleav age plane between the facial nerve and the tumor, and with the aid of the operating microscope this is usually achieved by fine dissection. A histological specimen of the nerve-tumor interface is available only if the facial nerve was hopelessly adherent to the tumor (usually a l arge or giant neoplasm) and the surgeon decided to sever the nerve to obtain a complete removal. The authors have examined immunohistochemic ally the nerve-tumor interface of 20 such facial nerves (six cases of neurofibromatosis 2 (NF2) and 14 of non-NF2) in a series of 351 acoust ic neurinomas. The largest extrameatal dimension of the 20 tumors rang ed from 20 to 51 mm (median 39 mm). In all of these 20 instances the nerve-tumor contact area was at least partially devoid of a clear-cut histological cleavage plane. Where the facial nerve trunk was attached to the surface of the tumor, nerve fibers of the contact areas either abutted directly against tumor cells or nerve fibers were seen to pen etrate into the tumor tissue. Frank embedding of nerve fibers was more frequent in NF2.