Clinicotopographic correlation of symptoms and signs in patients with
suspected ischemia within the vertebrobasilar territory is often diffi
cult. Even within the anatomically very complex brain stem a unifocal
lesion might not be able to explain all symptoms. Instead, multitopic
ischemic lesions might be the cause of the complex clinical picture. D
etailed clinical examination, electrophysiological brain stem testing,
vascular studies and imaging techniques can complement each other in
evaluation of functional and morphological multifocal ischemic brain s
tem disease. The underlying vascular pathology could be different in u
nifocal or multitopic ischemic lesions and might have impact on therap
y and prognosis.