AN AGGRESSIVE APPROACH TO MASSIVE MIDDLE CEREBRAL-ARTERY INFARCTION

Objective: We report favorable outcome after surgical decompression, o r strokectomy, guided by xenon-enhanced computed tomographic studies o f cerebral blood flow in the setting of potentially fatal swelling fro m massive cerebral infarction. Design: Retrospective analysis with 3 m onths to 3 years of follow-up. Setting: University of Pittsburgh (Pa) Medical Center, a tertiary care university referral center. Patients: Four patients, aged 14 to 46 years, presented with focal neurologic de ficits appropriate for a massive middle cerebral artery infarction (tw o dominant and two nondominant). In spite of medical therapy, all pati ents deteriorated to at least a decreased level of consciousness. Inte rvention: Using xenon-enhanced computed tomographic studies of cerebra l blood flow in three patients, areas of severely ischemic (blood flow , <5 ml/100 g per minute), nonviable brain were identified and resecte d. Outcome Measure: Outcome was measured by survival and ability to pe rform activities of daily living. Results: Postoperatively, all patien ts recovered rapidly (<6 hours) to the level of function at admission and were able to perform the activities of daily living with minimal o r no assistance. Conclusion: Despite deficits appropriate to the area of infarction, prompt management of life-threatening postinfarction sw elling by surgical decompression can yield favorable outcome.