Thioredoxin reductase is a member of a family of pyridine nucleotide d
isulfide oxidoreductases, flavoproteins known for their remarkable str
uctural homology. The enzyme is part of a thioredoxin complex which is
found in all types of organisms studied to date and performs a multit
ude of physiological functions. Thioredoxin reductase was shown to pro
tect skin against UV irradiation-induced oxygen free radicals. The enz
yme regulates the biosynthesis of melanin, thereby modulating suntan.