SYNTHESIS OF 19-HYDROXY DOCETAXEL FROM A NOVEL BACCATIN

Authors
MARGRAFF R BEZARD D BOURZAT JD COMMERCON A
Citation
R. Margraff et al., SYNTHESIS OF 19-HYDROXY DOCETAXEL FROM A NOVEL BACCATIN, Bioorganic & medicinal chemistry letters, 4(2), 1994, pp. 233-236
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
2
Year of publication
1994
Pages
233 - 236
Database
ISI
SICI code
0960-894X(1994)4:2<233:SO1DFA>2.0.ZU;2-O
Abstract
The synthesis of 19-hydroxy docetaxel is described starting from a new baccatin derivative, 4, which was extracted from the needles of Taxus Baccata. This analog exhibits a high level of cytotoxicity in in vitr o experimental models.