SYNTHESIS OF 2'-O-METHYL-6,3'-ETHANOURIDINE AND ITS INTRODUCTION INTOANTISENSE OLIGONUCLEOTIDES

Authors
BEVIERRE MO DEMESMAEKER A WOLF RM FREIER SM
Citation
Mo. Bevierre et al., SYNTHESIS OF 2'-O-METHYL-6,3'-ETHANOURIDINE AND ITS INTRODUCTION INTOANTISENSE OLIGONUCLEOTIDES, Bioorganic & medicinal chemistry letters, 4(2), 1994, pp. 237-240
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
2
Year of publication
1994
Pages
237 - 240
Database
ISI
SICI code
0960-894X(1994)4:2<237:SO2AII>2.0.ZU;2-1
Abstract
A molecular modelling study and a synthesis of title compound 1 are pr esented. This novel modified nucleoside was introduced into different oligonucleotides and the corresponding melting temperatures of the dup lexes formed with the complementary RNA were measured.