-DIMETHYL-1,2,3,4-TETRAHYDRO-6H-QUININDOLIN-1-ONE, A NOVEL GABA(A) MODULATOR WITH POTENTIAL ANXIOLYTIC ACTIVITY

Authors
BLACKBURN TP BOLTON D FORBES IT JOHNSON CN MARTIN RT THOMAS DR THOMPSON M UPTON N
Citation
Tp. Blackburn et al., -DIMETHYL-1,2,3,4-TETRAHYDRO-6H-QUININDOLIN-1-ONE, A NOVEL GABA(A) MODULATOR WITH POTENTIAL ANXIOLYTIC ACTIVITY, Bioorganic & medicinal chemistry letters, 4(2), 1994, pp. 279-284
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
2
Year of publication
1994
Pages
279 - 284
Database
ISI
SICI code
0960-894X(1994)4:2<279:-ANGM>2.0.ZU;2-G
Abstract
Ketone isosteres have been investigated in a series of pyrido[2,3-b]in doles (alpha-carbolines). The incorporation of ring fusion into alpha- carbolines to produce the rigid quinindoline nucleus provides a GABA(A ) modulator with both increased potency and a longer duration of actio n.