THE POSSIBLE ROLE OF A REPETITIVE AMINO-ACID MOTIF IN EVOLUTION OF TRITERPENOID CYCLASES

Authors
PORALLA K
Citation
K. Poralla, THE POSSIBLE ROLE OF A REPETITIVE AMINO-ACID MOTIF IN EVOLUTION OF TRITERPENOID CYCLASES, Bioorganic & medicinal chemistry letters, 4(2), 1994, pp. 285-290
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
2
Year of publication
1994
Pages
285 - 290
Database
ISI
SICI code
0960-894X(1994)4:2<285:TPROAR>2.0.ZU;2-9
Abstract
The motif Arg/Lys Gly/Ala X(2-3) Tyr/Phe/Trp Leu X(3) Gln X(2-5) Gly X Trp is repeated at aligned positions in the C-terminus of triterpenoi d cyclases. It is hypothesized that this motif may be involved in the binding and/or catalysis of squalene and oxidosqualene during the poly cyclization reaction. An evolutionary mechanism is proposed for differ ent triterpenoid cyclases, involving stepwise evolution of new motifs or inactivation of existing ones.