DIFFERENTIAL BINDING AND DOPAMINE UPTAKE ACTIVITY OF COCAINE ANALOGS MODIFIED AT NITROGEN

Authors
STOELWINDER J ROBERTI M KOZIKOWSKI AP JOHNSON KM BERGMANN JS
Citation
J. Stoelwinder et al., DIFFERENTIAL BINDING AND DOPAMINE UPTAKE ACTIVITY OF COCAINE ANALOGS MODIFIED AT NITROGEN, Bioorganic & medicinal chemistry letters, 4(2), 1994, pp. 303-308
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
2
Year of publication
1994
Pages
303 - 308
Database
ISI
SICI code
0960-894X(1994)4:2<303:DBADUA>2.0.ZU;2-P
Abstract
Syntheses of a variety of new N-modified cocaine analogues are reporte d together with their binding affinities and dopamine uptake inhibitio n activities. Compounds 3 and 13, which exhibit discrepancies in their binding and uptake potencies, were tested for their ability to antago nize cocaine's inhibition of dopamine reuptake.