A series of 2-(1,1-diphenylalkylamino)-1,3-diazaheterocycles was prepa
red and evaluated as antagonists of L-type calcium channels. Of the ei
ghteen derivatives in this series, tetrahydropyrimidine 6h and hexahyd
ro-1,3-diazocine 6n were the most potent calcium antagonists, being es
sentially equipotent to both diltiazem (2) and amidine 5.