HETEROCYCLIC GUANIDINES AS CALCIUM-ANTAGONISTS

Authors
KANE JM CARR AA CHENG HC DUDLEY MW RAMPE D STAEGER MA
Citation
Jm. Kane et al., HETEROCYCLIC GUANIDINES AS CALCIUM-ANTAGONISTS, Bioorganic & medicinal chemistry letters, 4(2), 1994, pp. 351-354
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
2
Year of publication
1994
Pages
351 - 354
Database
ISI
SICI code
0960-894X(1994)4:2<351:HGAC>2.0.ZU;2-J
Abstract
A series of 2-(1,1-diphenylalkylamino)-1,3-diazaheterocycles was prepa red and evaluated as antagonists of L-type calcium channels. Of the ei ghteen derivatives in this series, tetrahydropyrimidine 6h and hexahyd ro-1,3-diazocine 6n were the most potent calcium antagonists, being es sentially equipotent to both diltiazem (2) and amidine 5.