NUCLEOSIDES AND NUCLEOTIDES .127. A NOVEL AND CONVENIENT POST-SYNTHETIC MODIFICATION METHOD FOR THE SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES CARRYING AMINO LINKERS AT THE 5-POSITION OF 2'-DEOXYURIDINE

Authors
ONO A HAGINOYA N KIYOKAWA M MINAKAWA N MATSUDA A
Citation
A. Ono et al., NUCLEOSIDES AND NUCLEOTIDES .127. A NOVEL AND CONVENIENT POST-SYNTHETIC MODIFICATION METHOD FOR THE SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES CARRYING AMINO LINKERS AT THE 5-POSITION OF 2'-DEOXYURIDINE, Bioorganic & medicinal chemistry letters, 4(2), 1994, pp. 361-366
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
2
Year of publication
1994
Pages
361 - 366
Database
ISI
SICI code
0960-894X(1994)4:2<361:NAN.AN>2.0.ZU;2-C
Abstract
5-Methoxycarbonyl-2'-deoxyuridine has been synthesized and incorporate d in oligonucleotides. The fully protected oligonucleotides were treat ed with diaminoethane or diaminohexane and the oligonucleotides were d eprotected and purified to give oligonucleotides carrying amino-linker s, which were further derivatized with an intercalator. Properties of these oligonucleotides are described.