NUCLEOSIDES AND NUCLEOTIDES .128. (2'S)-2'-DEOXY-2'-C-METHYL-5-IODOURIDINE (SMIU) AS A NOVEL POTENT ANTI-HERPES VIRUS AGENT

Authors
AWANO H SHUTO S BABA M KIRA T SHIGETA S MATSUDA A
Citation
H. Awano et al., NUCLEOSIDES AND NUCLEOTIDES .128. (2'S)-2'-DEOXY-2'-C-METHYL-5-IODOURIDINE (SMIU) AS A NOVEL POTENT ANTI-HERPES VIRUS AGENT, Bioorganic & medicinal chemistry letters, 4(2), 1994, pp. 367-370
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
2
Year of publication
1994
Pages
367 - 370
Database
ISI
SICI code
0960-894X(1994)4:2<367:NAN.(>2.0.ZU;2-Y
Abstract
(2'S)-2'-deoxy-2'-C-methyl-5-halogenopyrimidine nucleosides were desig ned and synthesized as anti-herpes virus agents. Of these compounds, ( 2'S)-2'-deoxy-2'-C-methyl-5-iodouridine (SMIU, 9e) showed the greatest anti-HSV-l activity in vitro while showing no cytotoxicity. SMIU is a candidate drug for clinical treatment of herpes virus infection disea se.