NEUROLEPTICS DIFFERENTIALLY INDUCE JUN FAMILY GENES IN THE RAT STRIATUM

Authors
ROGUE P MALVIYA AN
Citation
P. Rogue et An. Malviya, NEUROLEPTICS DIFFERENTIALLY INDUCE JUN FAMILY GENES IN THE RAT STRIATUM, NeuroReport, 5(4), 1994, pp. 501-503
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
NeuroReport → ACNP
ISSN journal
09594965
Volume
5
Issue
4
Year of publication
1994
Pages
501 - 503
Database
ISI
SICI code
0959-4965(1994)5:4<501:NDIJFG>2.0.ZU;2-K
Abstract
THE effect of neuroleptics in single administration on the expression of genes of the jun family was studied in the rat striatum. jun B, but not jun D was dose-dependently and transiently induced. This effect w as blocked by pretreatment with a specific dopamine D-2 agonist. The e xpression of c-jun was also stimulated, although this did not reach st atistical significance. Thus dopamine D-2 receptors differentially reg ulate the expression of jun family members in the striatum.