METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS IN EUROPE

In order to obtain pan-European data on methicillin-resistant Staphylo coccus aureus (MRSA), 43 laboratories from ten European countries each screened 200 consecutive Staphylococcus aureus isolates for methicill in resistance. Only one isolate per patient was permitted. All partici pants used a uniform oxacillin-supplemented screening plate. MRSA isol ates were sent to Munich for reconfirmation and further susceptibility testing. Phage typing of the MRSA strains was performed in Denmark. O f the 7,333 Staphylococcus aureus strains screened, 936 (12.8 %) were methicillin resistant. The proportion of MRSA in the various European countries ranged from < 1 % in Scandinavia to > 30 % in Spain, France and Italy. Rates of resistance to the non-glycopeptide antibiotics wer e lowest for rifampin and highest for ciprofloxacin. Sixty percent of the methicillin-resistant strains originated from patients in surgical and medical departments, with wounds being the most common isolation source. MRSA was found more frequently in intensive care patients. Onl y 13 % of the strains were non-typable, and 76 % of the isolates belon ged to phage group III. For each area phage typing detected one or a f ew dominating (epidemic) types, but 46 % of the strains did not belong to these types; the MRSA population is thus a mixture of epidemic and non-epidemic strains. MRSA seems to be a growing problem, especially in southern Europe, where incidence and rates of antibiotic resistance are alarmingly high.