We report on two patients who have high titres of antiphospholipid ant
ibodies, both of whom had acute audiovestibular failure. One of the pa
tients had systemic lupus erythematosus. The other patient had primary
antiphospholipid syndrome: audiovestibular symptoms have not been rep
orted in this condition. The occurrence of acute audiovestibular failu
re in the primary antiphospholipid syndrome raises the question as to
whether patients presenting with acute deafness or vestibular disturba
nce should be screened for the presence of anticardiolipin antibodies.