PROLONGED EXTREME THROMBOCYTOSIS ASSOCIATED WITH NEUROFIBROMATOSIS TYPE-1

Authors
HASLE H NIR M TOMMERUP N
Citation
H. Hasle et al., PROLONGED EXTREME THROMBOCYTOSIS ASSOCIATED WITH NEUROFIBROMATOSIS TYPE-1, The Journal of pediatrics, 130(2), 1997, pp. 317-319
Citations number
14
Categorie Soggetti
Pediatrics
Journal title
The Journal of pediatrics → ACNP
ISSN journal
00223476
Volume
130
Issue
2
Year of publication
1997
Pages
317 - 319
Database
ISI
SICI code
0022-3476(1997)130:2<317:PETAWN>2.0.ZU;2-H
Abstract
A girl with neurofibromatosis type 1 showed in infancy extreme thrombo cytosis with platelet counts exceeding 2000 x 10(9)/L. Platelet counts remained elevated the first 4 years of life. A large deletion located at chromosome 17q11 was observed. The transient thrombocythemia may r elate to a regulator of mega-karyocytopoiesis located in the vicinity of the NF1 gene or to the excessive risk of chronic myelomonocytic leu kemia in neurofibromatosis.