IDENTIFICATION OF A GENETIC-LOCUS INVOLVED IN THE BIOSYNTHESIS OF N-ACETYL-D-MANNOSAMINE, A PRECURSOR OF THE (ALPHA-2-]8)-LINKED POLYSIALICACID CAPSULE OF SEROGROUP-B NEISSERIA-MENINGITIDIS

Authors
SWARTLEY JS STEPHENS DS
Citation
Js. Swartley et Ds. Stephens, IDENTIFICATION OF A GENETIC-LOCUS INVOLVED IN THE BIOSYNTHESIS OF N-ACETYL-D-MANNOSAMINE, A PRECURSOR OF THE (ALPHA-2-]8)-LINKED POLYSIALICACID CAPSULE OF SEROGROUP-B NEISSERIA-MENINGITIDIS, Journal of bacteriology, 176(5), 1994, pp. 1530-1534
Citations number
27
Categorie Soggetti
Microbiology
Journal title
Journal of bacteriology → ACNP
ISSN journal
00219193
Volume
176
Issue
5
Year of publication
1994
Pages
1530 - 1534
Database
ISI
SICI code
0021-9193(1994)176:5<1530:IOAGII>2.0.ZU;2-2
Abstract
We characterized the genetic defect of a capsule-deficient serogroup B meningococcal strain created by Tn916 mutagenesis. The transposon ins ertion interrupts a capsule biosynthesis gene, synX, which is involved in the production of N-acetyl-D-mannosamine, a precursor of the (alph a 2-->8)-linked polysialic acid capsule of serogroup B meningococci.