REPEATED D-1 RECEPTOR AGONIST TREATMENT BLOCKS COCAINE-INDUCED LOCOMOTOR-ACTIVITY AND C-FOS EXPRESSION

Authors
ASIN KE NIKKEL AL WIRTSHAFTER D
Citation
Ke. Asin et al., REPEATED D-1 RECEPTOR AGONIST TREATMENT BLOCKS COCAINE-INDUCED LOCOMOTOR-ACTIVITY AND C-FOS EXPRESSION, Brain research, 637(1-2), 1994, pp. 342-344
Citations number
14
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
637
Issue
1-2
Year of publication
1994
Pages
342 - 344
Database
ISI
SICI code
0006-8993(1994)637:1-2<342:RDRATB>2.0.ZU;2-0
Abstract
Pretreatment of rats for 4 days with the selective dopamine D, recepto r agonist A-77636 attenuated the ability of cocaine to induce locomoto r hyperactivity and to stimulate the expression of the proto-oncogene c-fos in the striatum and nucleus accumbens. Our results suggest that repeated D-1 agonist treatment leads to subsensitivity of D-1 receptor s involved in mediating some of the effects of cocaine on behavior and gene expression.