DIFFERENTIATION OF NEOPLASTIC-CELLS TOWARD NORMAL INDUCED BY VITAMIN-D-3 DERIVATIVES

Authors
SRIVASTAVA MD DELUCA HF AMBRUS JL
Citation
Md. Srivastava et al., DIFFERENTIATION OF NEOPLASTIC-CELLS TOWARD NORMAL INDUCED BY VITAMIN-D-3 DERIVATIVES, Research communications in chemical pathology and pharmacology, 83(2), 1994, pp. 115-123
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Pathology
Journal title
Research communications in chemical pathology and pharmacology → ACNP
ISSN journal
00345164
Volume
83
Issue
2
Year of publication
1994
Pages
115 - 123
Database
ISI
SICI code
0034-5164(1994)83:2<115:DONTNI>2.0.ZU;2-N
Abstract
Two new analogs of 1,25 dihydroxy vitamin D-3 (calcitriol, DHCC), the active metabolite of vitamin D-3 (cholecalciferol (D-3) are less activ e on calcium metabolism and less toxic than (DHCC). They had increased differentiation-inducing activity towards normal on human myeloblasti c leukemia cell line HL-60 and on histiocytic lymphoma cell line U-937 consisting of monoblastoid cells. 1,2 tetradeconyl phorbol 1, 3 aceta te (TPA) was used as a positive control in these experiments.