INHIBITION OF IL-6 AND IL-8 PRODUCTION IN HUMAN FIBROBLAST CELL-LINESBY 1,25 (OH)(2) VITAMIN-D-3 AND 2 OF ITS ANALOGS WITH LOWER CALCEMIC ACTIVITY

Authors
SRIVASTAVA MD DELUCA H AMBRUS JL
Citation
Md. Srivastava et al., INHIBITION OF IL-6 AND IL-8 PRODUCTION IN HUMAN FIBROBLAST CELL-LINESBY 1,25 (OH)(2) VITAMIN-D-3 AND 2 OF ITS ANALOGS WITH LOWER CALCEMIC ACTIVITY, Research communications in chemical pathology and pharmacology, 83(2), 1994, pp. 145-150
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Pathology
Journal title
Research communications in chemical pathology and pharmacology → ACNP
ISSN journal
00345164
Volume
83
Issue
2
Year of publication
1994
Pages
145 - 150
Database
ISI
SICI code
0034-5164(1994)83:2<145:IOIAIP>2.0.ZU;2-I
Abstract
In human fibroblast cultures TPA increased IL-6 and IL-8 production. T his was reduced by vitamin D-3 metabolites and analogs. The two analog s employed: 1,25 (OH)(2) -22 (E)-dehydro-24-monohomo vitamin D-3 (Comp ound A) and 1,25 (OH)(2) -22 (E)-dehydro-24 dihomo-vitamin D-3 (Compou nd B) may be useful in the therapy of pathologic proliferative disorde rs including psoriasis, particularly since they are less toxic and hav e less effect on calcium metabolism than vitamin D-3.