EVALUATION OF MYOSIN-REACTIVE ANTIBODIES FROM A PANEL OF MYASTHENIA-GRAVIS PATIENTS

Citation
S. Mohan et al., EVALUATION OF MYOSIN-REACTIVE ANTIBODIES FROM A PANEL OF MYASTHENIA-GRAVIS PATIENTS, Clinical immunology and immunopathology, 70(3), 1994, pp. 266-273
Citations number
52
Categorie Soggetti
Pathology,Immunology
ISSN journal
00901229
Volume
70
Issue
3
Year of publication
1994
Pages
266 - 273
Database
ISI
SICI code
0090-1229(1994)70:3<266:EOMAFA>2.0.ZU;2-D
Abstract
In the study described below, 97 myasthenia gravis (MG) patients have been evaluated for antibody reactivity against muscle myosin. With few exceptions, we could clearly observe a positive correlation between t he presence of circulating serum anti-myosin antibodies and disease se verity. Unlike some studies of anti-striational antibodies in MG patie nts, no association with thymoma was apparent. Moreover, no relationsh ips were revealed between the severity of disease symptoms demonstrate d and absolute anti-myosin antibody titers or prominent IgG subclasses . Therefore, we suggest that expression of myosin reactivity may be on e useful parameter for predicting disease severity in those patients, but it is not prerequisite for induction of MG. (C) 1991 Academic Pres s, Inc.