BIOTECHNOLOGY IN PROFILED DIALYSIS

Profiled dialysis is a new conceptual approach to patient intradialyti c vascular instability. It is based on the continuous modulation of di alysis operative parameters, such as dialysate sodium and UF rate, acc ording to pre-established profiles. The points to be defined for profi led dialysis are: (a) the patient's individual sodium and masses alrea dy stated; (b) the patient's individual algorithms to ht the clinicall y effective intradialytic variations in plasma sodium and sodium mass; (c) a mathematical model from which sodium and UF profiles are automa tically worked out at the beginning of each session. The basic concept of profiled dialysis should evolve towards an ongoing 'profiling' pro gramme. This is based on the continuous on-line intradialytic adjustme nt of profiles according to the patient's emerging clinical requiremen ts.