BORRELIA BURGDORFERI-ASSOCIATED PRIMARY CUTANEOUS B-CELL LYMPHOMA - COMPLETE CLEARING OF SKIN-LESIONS AFTER ANTIBIOTIC PULSE THERAPY OR INTRALESIONAL INJECTION OF INTERFERON ALFA-2A

We report two patients with low-grade malignant primary cutaneous B ce ll lymphoma in association with Borrelia burgdorferi infection. Extrac utaneous manifestations were ruled out by standard staging procedures. Infection with Borrelia burgdorferi was confirmed by cultivation from lesional skin in both patients. In the first patient skin lesions cle ared completely after pulse therapy with cefotaxime, whereas in the se cond patient antibiotic treatment failed. In this patient, however, sk in lesions completely cleared after intralesional injection of interfe ron alfa-2a. Antibiotic treatment or intralesional injection of interf eron alfa-2a should be considered as a first-line treatment of Borreli a burgdorferi-associated primary cutaneous B cell lymphoma before more aggressive conventional therapeutic modalities (e.g., radiation thera py) are applied.