1H-1,2,4-TRIAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - C-LINKED ANALOGS OF SC-50560

Authors
REITZ DB PENICK MA NORTON MB REINHARD EJ OLINS GM CORPUS VM PALOMO MA MCGRAW DE MCMAHON EG
Citation
Db. Reitz et al., 1H-1,2,4-TRIAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - C-LINKED ANALOGS OF SC-50560, Bioorganic & medicinal chemistry letters, 4(1), 1994, pp. 105-110
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
1
Year of publication
1994
Pages
105 - 110
Database
ISI
SICI code
0960-894X(1994)4:1<105:1ARA-C>2.0.ZU;2-L
Abstract
Novel 1H-1,2,4-triazole analogs in which the biphenylmethyl group is a ttached to carbon and the butyl group is attached to the adjacent nitr ogen were found to be potent angiotensin II receptor antagonists. Addi tional substitution at the carbon bearing the biphenyl group proved to be very detrimental to potency. The in vivo properties of the dibutyl analog SC-51757 were found to be similar to SC-50560.