Novel 1H-1,2,4-triazole analogs in which the biphenylmethyl group is a
ttached to carbon and the butyl group is attached to the adjacent nitr
ogen were found to be potent angiotensin II receptor antagonists. Addi
tional substitution at the carbon bearing the biphenyl group proved to
be very detrimental to potency. The in vivo properties of the dibutyl
analog SC-51757 were found to be similar to SC-50560.