N-1-STERICALLY HINDERED 2H-IMIDAZOL-2-ONE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - THE SYNTHESIS OF [H-3] SC-54628 AND [H-3] SC-54629

Authors
REITZ DB GARLAND DJ OLINS GM MARKOS CS GRESK CJ LITSCHGI JW MCKINNIS BR
Citation
Db. Reitz et al., N-1-STERICALLY HINDERED 2H-IMIDAZOL-2-ONE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - THE SYNTHESIS OF [H-3] SC-54628 AND [H-3] SC-54629, Bioorganic & medicinal chemistry letters, 4(1), 1994, pp. 111-114
Citations number
4
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
1
Year of publication
1994
Pages
111 - 114
Database
ISI
SICI code
0960-894X(1994)4:1<111:NH2ARA>2.0.ZU;2-J
Abstract
Radiolabeled 2H-imidazol-2-one angiotensin II AT(1) receptor antagonis ts [H-3]-SC-54628 and [H-3]-SC-54629 have been synthesized from CBZ-gy lcine. These radioligands have nominally four tritium atoms incorporat ed into the butyl group at the 4-position of the 2H-imidazol-2-ones.