NEW NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS .1. STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF 2(1H)-PYRIDINONES

Authors
BANTICK JR BEATON HG COOPER SL HILL S HIRST SC MCINALLY T SPENCER J TINKER AC WILLIS PA
Citation
Jr. Bantick et al., NEW NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS .1. STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF 2(1H)-PYRIDINONES, Bioorganic & medicinal chemistry letters, 4(1), 1994, pp. 121-126
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
1
Year of publication
1994
Pages
121 - 126
Database
ISI
SICI code
0960-894X(1994)4:1<121:NNARA.>2.0.ZU;2-Q
Abstract
The synthesis and AII antagonist activities of a series of biphenyl 2( 1H)-pyridinones is described. 4-Hydroxy- and 4-carboxy-substituted pyr idinones are particularly potent, both in vitro and in vivo.