1-4-SUBSTITUTED INDOLES - A POTENT AND SELECTIVE CLASS OF ANGIOTENSIN-II RECEPTOR ANTAGONISTS

Authors
POSS MA GU ZX RYONO DE REID JA SIEBERMCMASTER E SPITZMILLER ER DEJNEKA T DICKINSON KEJ WILLIAMS SB MORELAND S DELANEY CL BIRD JE WALDRON TL SCHAEFFER TR HEDBERG SA PETRILLO EW
Citation
Ma. Poss et al., 1-4-SUBSTITUTED INDOLES - A POTENT AND SELECTIVE CLASS OF ANGIOTENSIN-II RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 4(1), 1994, pp. 145-150
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
1
Year of publication
1994
Pages
145 - 150
Database
ISI
SICI code
0960-894X(1994)4:1<145:1I-APA>2.0.ZU;2-U
Abstract
The syntheses and pharmacological activity of a series of 1,4-substitu ted indoles which function as nonpeptidic antagonists of the angiotens in II (AII) receptor are described. Compounds in this series are orall y active and demonstrate long lasting antihypertensive activity.