QUINOLINE-4-CARBOXYLIC ACIDS AS ANGIOTENSIN-II RECEPTOR ANTAGONISTS

Authors
LLOYD J RYONO DE BIRD JE BUOTE J DELANEY CL DEJNEKA T DICKINSON KEJ MORELAND S NORMANDIN DE SKWISH S SPITZMILLER ER WALDRON TL
Citation
J. Lloyd et al., QUINOLINE-4-CARBOXYLIC ACIDS AS ANGIOTENSIN-II RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 4(1), 1994, pp. 195-200
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
1
Year of publication
1994
Pages
195 - 200
Database
ISI
SICI code
0960-894X(1994)4:1<195:QAAARA>2.0.ZU;2-1
Abstract
We have synthesized a series of quinoline-4-carboxylic acids that are potent antagonists of the angiotensin II receptor. They show high rece ptor binding affinities and functional antagonism in rabbit aortic str ips. They are also effective in blocking the hypertensive effects of A II in vivo.