PATTERNS OF ONCOGENE ACTIVATION IN HUMAN NEUROBLASTOMA-CELLS

Authors
CORVI R SAVELYEVA L SCHWAB M
Citation
R. Corvi et al., PATTERNS OF ONCOGENE ACTIVATION IN HUMAN NEUROBLASTOMA-CELLS, Journal of neuro-oncology, 31(1-2), 1997, pp. 25-31
Citations number
38
Categorie Soggetti
Clinical Neurology",Oncology
Journal title
Journal of neuro-oncology → ACNP
ISSN journal
0167594X
Volume
31
Issue
1-2
Year of publication
1997
Pages
25 - 31
Database
ISI
SICI code
0167-594X(1997)31:1-2<25:POOAIH>2.0.ZU;2-I
Abstract
Human neuroblastoma is the most frequent solid tumor in children. Rece nt studies suggest that a multiplicity of genomic alterations contribu tes to neuroblastoma, the most frequent and well studied being deletio n of the short arm of chromosome 1 and amplification of N-MYC. We here present and discuss different patterns of oncogene activation includi ng, amplification of N-MYC, duplication of N-MYC and amplification of MDM2.