VINBLASTINE-INDUCED AUTOPHAGY IN MOUSE-LIVER

Authors
KROL T SCHMIDT M KOLATAJ A WITEK B
Citation
T. Krol et al., VINBLASTINE-INDUCED AUTOPHAGY IN MOUSE-LIVER, Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology, 107(1), 1994, pp. 165-169
Citations number
26
Categorie Soggetti
Biology,"Pharmacology & Pharmacy",Toxicology
Journal title
Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology → ACNP
ISSN journal
13678280
Volume
107
Issue
1
Year of publication
1994
Pages
165 - 169
Database
ISI
SICI code
1367-8280(1994)107:1<165:VAIM>2.0.ZU;2-H
Abstract
The vinblastine effect on the size of autophagy in a mouse liver cell was studied. The activity of cathepsin D and L, lysosomal esterase, N- acetylo-beta-glucosaminidase, beta-galactosidase, beta-glucuronidase, acid phosphatase was determined. In an isolated lysosomal fraction, it was found that vinblastine caused an increase of protein degradation of mouse hepatocytes and this action was dependent on dose and time of exposure. It was related to an increase in lysosomal compartment.