CELL-INDUCED IG ALLOTYPIC SUPPRESSION IN MICE - BASIS FOR EMERGENCE OR TOLERIZATION, DURING THE PERINATAL-PERIOD, OF NATURAL T-CELLS SPECIFIC TO THE IGG2A(B) ALLOTYPE
L. Majlessi et al., CELL-INDUCED IG ALLOTYPIC SUPPRESSION IN MICE - BASIS FOR EMERGENCE OR TOLERIZATION, DURING THE PERINATAL-PERIOD, OF NATURAL T-CELLS SPECIFIC TO THE IGG2A(B) ALLOTYPE, The Journal of immunology, 152(7), 1994, pp. 3342-3352
We have previously described an anti-IgG2a(b) T cell activity in norma
l Igh(a/a) mice. Their congenic partner at the Igh locus (Igh(b/b)) an
d Igh(a/b) hybrids bred from them, do not display this T cell activity
but express IgG2a(b). As these mice are supposed to possess the same
genetic elements related to this potential T cell repertoire, only som
atic selection mechanisms could be responsible for their different beh
avior. In this study, we investigated the basis for the emergence (in
Igh(a/a) mice) or tolerization (in Igh(b/b)-congenic mice and in Igh(a
/b) hybrids) of these natural anti-IgG2a(b) T cells. Stringent perinat
al B cell deprivation in Igh(b/b) and Igh(a/b) mice resulted in the em
ergence of anti-IgG2a(b) T cells, as these individuals could be subjec
ted to autoimmune, T cell-mediated IgG2a(b) suppression. Furthermore,
the acquisition of anti-IgG2a(b) T cell activity was drastically reduc
ed in Igh(a/a) mice, perinatally exposed to IgG2a(b); thus, the presen
ce of this allotype leads to tolerization of these specific T cells.