A fast process synthesis procedure is developed for generating prelimi
nary separation schemes. The main approach is based on similarity indi
ces obtained from chemical, physical and operating properties between
two chemical species in a separation scheme. For the whole set of spec
ies, a similarity matrix results. On this basis, algorithms for classi
fying chemical species and generating separation sequences are develop
ed. A distance between flowsheets is used in order to compare differen
t separation schemes with one another or to some reference cases. The
weights of the properties and heuristics are adjusted to account for w
ell-known optimal cases. Changes in the number of considered separatio
n properties and in their hierarchy are also used to improve the proce
dure. The algorithm requires very little calculation and can even be i
mplemented by hand in the simplest cases. Extensions of the algorithm
include the use of actual values of the separation properties instead
of boolean ones and the generation of non-sharp flowsheets.