The response to the bisphophosphonate, pamidronate, is reported in a c
hild with osteogenesis imperfecta who had recurrent symptomatic hyperc
alcaemia after immobilisation following fractures. Oral clodronate was
effective in the prevention of immobilisation hypercalcaemia in the s
ame child. The bisphosphonates may have other roles in osteogenesis im
perfecta by decreasing bone turnover.