HEPATITIS-B AND C VIRUS-INFECTION AS RISK-FACTORS FOR HEPATOCELLULAR-CARCINOMA IN CHINESE - A CASE-CONTROL STUDY

To assess whether hepatitis B and C virus infection were risk factors for hepatocellular carcinoma (HCC), antibody to hepatitis C virus (ant i-HCV), hepatitis B surface antigen and e antigen (HBsAg and HBeAg) we re tested in 150 HCC patients. Another 150 case-control pairs matched individually by sex and age were also enrolled. Univariate analysis de monstrated that both the anti-HCV and the carrier status of HBsAg and HBeAg were significantly associated with HCC. Multi-variate analysis r evealed that both anti-HCV and HBsAg were risk factors for HCC. The po pulation-attributable risk was estimated as 14.2% for anti-HCV alone, 59.4% for HBsAg alone and 8.0% for both anti-HCV and HBsAg in Taiwan. In conclusion, both hepatitis B and C virus infection are independent risk factors for HCC in Chinese in southern Taiwan. (C) 1994 Wiley-Lis s, Inc.