PHARMACOLOGICAL ACTIVITY OF CHEMICALLY-MODIFIED SUBFRAGMENT FROM HUMAN SERUM IGG .11. INCREMENT OF TUMOR-NECROSIS-FACTOR (TNF) ACTIVITY IN MOUSE SERA BY CARBOXAMIDE-METHYLATED LIGHT-CHAIN
T. Mimura et al., PHARMACOLOGICAL ACTIVITY OF CHEMICALLY-MODIFIED SUBFRAGMENT FROM HUMAN SERUM IGG .11. INCREMENT OF TUMOR-NECROSIS-FACTOR (TNF) ACTIVITY IN MOUSE SERA BY CARBOXAMIDE-METHYLATED LIGHT-CHAIN, Biological & pharmaceutical bulletin, 17(2), 1994, pp. 197-200
Intravenous administration of the carboxamide-methylated light chain (
G(1)L) from human serum IgG induced tumor necrosis factor (TNF), one o
f the inflammatory cytokines, in the serum of mice. Human serum IgG, h
owever, showed no induction of TNF in the serum. G(1)L showed a potent
anti-inflammatory effect in carrageenin-induced paw edema, and the an
ti-inflammatory effect of G(1)L was significantly blocked by the conco
mitant administration of anti-TNF antiserum, but TNF alone had no anti
-inflammatory effect.