PHARMACOLOGICAL ACTIVITY OF CHEMICALLY-MODIFIED SUBFRAGMENT FROM HUMAN SERUM IGG .11. INCREMENT OF TUMOR-NECROSIS-FACTOR (TNF) ACTIVITY IN MOUSE SERA BY CARBOXAMIDE-METHYLATED LIGHT-CHAIN

Citation
T. Mimura et al., PHARMACOLOGICAL ACTIVITY OF CHEMICALLY-MODIFIED SUBFRAGMENT FROM HUMAN SERUM IGG .11. INCREMENT OF TUMOR-NECROSIS-FACTOR (TNF) ACTIVITY IN MOUSE SERA BY CARBOXAMIDE-METHYLATED LIGHT-CHAIN, Biological & pharmaceutical bulletin, 17(2), 1994, pp. 197-200
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
09186158
Volume
17
Issue
2
Year of publication
1994
Pages
197 - 200
Database
ISI
SICI code
0918-6158(1994)17:2<197:PAOCSF>2.0.ZU;2-K
Abstract
Intravenous administration of the carboxamide-methylated light chain ( G(1)L) from human serum IgG induced tumor necrosis factor (TNF), one o f the inflammatory cytokines, in the serum of mice. Human serum IgG, h owever, showed no induction of TNF in the serum. G(1)L showed a potent anti-inflammatory effect in carrageenin-induced paw edema, and the an ti-inflammatory effect of G(1)L was significantly blocked by the conco mitant administration of anti-TNF antiserum, but TNF alone had no anti -inflammatory effect.